Biosensors enable label-free monitoring of live cells

 

 

Alumna Zhuo Receives Postdoctoral Scholar Award

Yue Zhuo, PHD ’15 BIOE and postdoctoral fellow at the University of Illinois at Urbana-Champaign, recently earned the 2017 Microscopy and Microanalysis Postdoctoral Scholar Award for her conference paper, “Label-free Imaging of Stem Cell Adhesion and Dynamic Tracking of Boundary Evolution using Photonic Crystal Enhanced Microscopy” (PCEM). The Microscopy Society of America presented the award in August 2017 at the Microscopy and Microanalysis annual meeting in St. Louis.

The PCEM imaging system relies on photonic crystal biosensors to enable label-free monitoring of live cells. The system is a new tool for measuring single-cell behavior that may hold great potential for studying cell-surface attachment profiles, cell-substrate interactions and cell-drug responses. PCEM data can potentially provide unique information for building cell-substrate interaction models with subcellular details. By gathering such information for multiple cell types and environmental conditions, PCEM can enable the construction of a “quantitative live cell footprint library” and provide a useful resource for biomedical and biomaterial research. The ultimate goal is to assist research in wound healing, stem cell therapy, and cancer treatment.

Zhuo, who is collaborating on this project with UI professors Brian Cunningham and Brendan Harley, is a fellow at the Beckman Institute for Advanced Science and Technology and member of Cunningham’s nanosensors research group.

Zhuo provides a more complete description of the research in her recent paper, “Quantitative Imaging of Cell Membrane-associated Effective Mass Density using Photonic Crystal Enhanced Microscopy,” published November 2016 in the journal Progress in Quantum Electronics.