Paul R. Selvin
Ph.D., Physics, University of California-Berkeley, 1990
- Research Interests:
- Ion channels — structure and dynamics of voltage-controlled ion channels that are responsible for nerve impulses.
- Actomyosin — structure and dynamics of myosin and its interaction with actin, the two proteins responsible for muscle contraction.
- High-throughput-screening of drugs — developing novel non-radioactive assays for rapid, sensitive and simple method for rapid screening of potential drugs and their effect on interaction of biomolecules.
- Protein dynamics —electron transport in bacterial chlorophyll.
- Development of advanced resonance energy transfer techniques, including single molecule fluorescence and lanthanide-based assays.
- Development of long-lived luminescent probes based on lanthanide luminescence.
- (Ph.D. thesis title: DNA Dynamics: From Picoseconds to Milliseconds)
- Detected single fluorescent molecules and energy transfer between a single donor-acceptor pair via Near-Field Scanning Optical Microscopy.
- Measured voltage-dependent conformational changes in voltage-controlled ion channel, using lanthanide-based resonance energy transfer.
- Measured conformational changes in myosin head as a function of actin and nucleotide binding using lanthanide-based resonance energy transfer.
- Developed new luminescent lanthanide chelates which are alternatives to fluorescent dyes, and are particularly useful for discriminating against background fluorescence. This includes their synthesis, photophysical characterization and atomic (x-ray) structure.
- Developed new energy-transfer technique based on these lanthanide chelates, and built the appropriate spectrometer. A 100-fold improvement in signal to background over conventional fluorescence energy transfer has been achieved.
- Used picosecond fluorescence spectroscopy to detect anharmonic torsional modes in DNA.
- For more information:
- Paul Selvin - Curriculum Vitae
- Paul Selvin - Personal Web Page
Honors, Recognition, and Outstanding Achievements for Teaching:
- List of Teachers Ranked as Excellent, Fall 1999, Fall 2001, Spring 2002, Spring 2003.
- National Science Foundation CAREER Award for Outstanding Research/Teaching (2000)
Honors, Recognition, and Outstanding Achievements for Research:
- Nikon Fellowship, Marine Biological Laboratory, Woods Hole, Massachusetts (2010)
- The International Raymond and Beverly Sackler Prize in Biophysics, Tel Aviv University (2006)
- University Scholar, University of Illinois Urbana-Champaign (2006-2007)
- Faculty Member of the Precision Proteomics Research Theme, Institute for Genomic Biology (2005-present)
- Fellow, American Physical Society (2004-present)
- Physics Sony Faculty Scholar (2004-2007)
- Elected to General council of Biophysical Society (2004)
- Biophysical Society Michael and Kate Barany Award for Young Investigators (2004)
- Beckman Fellow, Center for Advanced Studies, Urbana (Spring 2000)
- Cottrell Scholar, Research Corporation (2000)
- Xerox Award for Outstanding Research (2000)
- Research Innovation Award, Research Corp. (1999)
- Young Fluorescence Investigator Award, Biophysical Society (1999)
- Searle Fellowship nominee from Urbana (1997-1998)
- P.I. of NIH grant ranked in top 2.4% (5 year funding beginning 1996)
- Co-author of NIH grants ranked in top 4% (4 year funding beginning 1994) and top 11% (5 year funding beginning 1988)
- AAAS Mass Media Science and Engineering Fellow (1990)
- Office of Technology Assessment Congressional Fellow Winner (1990)
- National Science Foundation Graduate Student Fellowship (1983-86)